barrier repair
PDRN
피디알엔 · PDRN
Also known as: Polydeoxyribonucleotide, Salmon DNA
What it actually does
A salmon-derived ingredient used topically in some cosmetic formulations. Interest in topical PDRN is emerging in Korean skincare, but this is distinct from injectable, in-clinic PDRN, for which more clinical evidence exists.
How to use it
Best in a serum or ampoule at night, on freshly cleansed skin. Give it 8–12 weeks of consistent use.
The science, in plain English
A DNA fragment typically derived from salmon. In-clinic, injectable PDRN has more established clinical study behind it than the topical, cosmetic form; topical PDRN skincare is an area of emerging formulation interest rather than an established clinical treatment.
Myth vs reality
Topical PDRN skincare is not the same as an in-clinic PDRN injection, and should not be assumed to work the same way or produce comparable results.
Limitations of the evidence
Clinical evidence for topical PDRN specifically is limited compared with the in-clinic injectable form; brand and marketing claims about topical PDRN often outpace the available evidence. Treat "designed to support the look of tired or stressed skin" as a formulation intention, not a proven outcome.
Who may need extra caution
People with fish or seafood allergies may want to avoid salmon-derived ingredients.
Evidence review date
Not yet reviewed
Sources
Not yet reviewed
Pairs well with
- Peptides
- Ceramides
- Panthenol
Don't layer with
- Strong AHAs/BHAs in the same routine step
Shop products with PDRN
No products in our catalogue are tagged with this ingredient yet — check back soon.